| Split-brain | Splog | SPOF |
| Spoiler | Spondias | Spondias bipinnata |
| Spondias dulcis | Spondias mombin | Spondias pinnata |
| Spondias purpurea | Spondylodesis | Spondylosyndesis |
| Sponge | Sponge (TV series) | Sponge ฉลาดสุด...สุด |
| Sponge ฉลาดสุดสุด | SPONGE ฉลาดสุดสุด | SpongeBob SquarePants |
| Spongilla lacustris | Spongillidae | Spongy bone |
| Spontaneous bacterial peritonitis | Spontaneous confabulation | Sporades |
| Spore | SPORE | Sport Bike |
| Sport psychology | Sport Ranger | Sport Rangers |
| Sportcity | Sporting Clube de Portugal | Sporting CP |
| Sporting de Gijón | Sporting Lisbon | Sportranger |
| Sportrangers | Sports Authority of Thailand | Spot price |
| Spotfin lionfish | Spotify | Spotlight (film) |
| Spotted arowana | Spotted barb | Spotted Bass |
| Spotted boxfish | Spotted hyena | Spotted owlet |
| Spotted pond turtle | SPR | Sprig of Acacia |
| Spring Airlines | Spring and Autumn period | Spring break |
| Spring News | Spring Snow | Spring Stampede |
| Spring Symphony | Spring Waltz | Spring, Summer, Fall, Winter... and Spring |
| Springboard | Springbok | Springnews |
| Sprite (soft drink) | SPSS | Spurdog |
| Sputnik | Sputnik 1 | Sputum |
| Spy vs. Spy | Spyware | SQL |
| Sql | SQL Server | Sql server |
| SQLObject | Squaliformes | Squaloidei |
| Squalus | Squalus maximus | Squalus microcephalus |
| Squalus mitsukurii | Squalus spathula | Squamata |
| Squamosal suture | Square bipyramid | Square cupola |
| Square dipyramid | Square Enix | Square gyrobicupola |
| Square orthobicupola | Square pulse | Square pyramid |
| Squash | Squatina | Squatinidae |
| Squatiniformes | Squatter | Squatters |
| Squatting | Squid | Squid (software) |
| Squint | Sqweez animal | Sqweez Animal |
| Sqweeze animal | Sr | SRAM |
| SRAM Corporation | Srđan Lakić | Sri Lanka |
| Sri Lanka junglefowl | Sri Lanka Matha | Sri Lankan elephant |
| Sri Pada | Sri Petaling Line | Srinagar |
| Sripatum Business school | Srisaket Sor Rungvisai | Srivijaya |
| SRT | SRW | SS |
| SS Archimedes | SS-1 Scud | SS-Totenkopfverbände |
| Ss501 | SS501 | SSD |
| SSH | Ssh | Ssiquoya |
| SSL | SSL/TLS | SSRI |
| SSRI discontinuation syndrome | SSRIs | SSS..S..S |
| St Agnes | St Albans Cathedral | St Bartholomew |
| St Christopher | St Dunstan | St Edward the Confessor |
| St Edward's Chair | St Francis of Assisi | St Germain-en-Laye |
| St Gregory | St James the Greater | St James' Park |
| St James's Palace | St John Chrysostom | St Mark's Basilica |
| St Paul | St Paul the Apostle | St Paul's Cathedral |
| St Pauls Cathedral | St Peter's Basilica | ST Plaza |
| ST segment | St Thomas Becket | St Thomas of Canterbury |
| St Vigilius | St-Germain-en-Laye | St. Alban of Mainz |
| St. Albert the Great | St. Ambrose | St. Andrew |
| St. Andrews University | St. Anne | St. Anthony the Great |
| St. Augustine of Hippo | St. Bartholomew's Day Massacre | St. Bartholomew’s Day massacre |
| St. Bridget of Sweden | St. Catharines | St. Cecilia |
| St. Charles, Missouri | St. Chrysostom | St. Croix |
| St. Dunstan | St. Edward's Crown | St. Francis |
| St. Francis of Assisi | St. Gallen | St. George (Raphael) |
| St. George and the Dragon (Raphael) | St. George's, Grenada | St. Germain-en-Laye |
| St. James | St. James' Way | St. James's |
| St. James's Palace | St. James's Park tube Station | St. James’s Palace |
| St. Jerome | St. Jerome in His Study (Antonello da Messina) | St. Jerome in the Wilderness |
| St. John | St. John Chrysostom | St. John the Baptist |
| St. John the Baptist (Gaulli) | St. John the Evangelist | St. Joseph |
| St. Louis | St. Louis, Missouri | St. Louis, MO |
| St. Luke the Evangelist | St. Mark the Evangelist | St. Mark's Basilica |
| St. Mark's, Venice | St. Martin of Tours | St. Mary Magdalene |
| St. Matthew the Evangelist | St. Moritz | St. Odo of Cluny |
| St. Otto of Bamberg | St. Paul | St. Paul Cathedral |
| St. Paul the Apostle | St. Paul's Cathedral | St. Paulinus of York |
| St. Peter's baldachin | St. Peter's Basilica | St. Petersburg |
| St. Petersburg University | St. Sebastian | St. Sigismund |
| St. Stephen | St. Stephen's Cathedral | St. Stephen's Cathedral, Vienna |
| St. Thomas Aquinas | St. Thomas Becket | St. Thomas of Canterbury |
| St. Vigilius | St.-Germain-en-Laye | Stabilo |
| Stachyridopsis rufifrons | Stachyris rodolphei | Stachys sieboldii |
| Stachytarpheta jamaicensis | Stack | Stack glass |
| Stacked glass | Stacked glass / Stack glass | Stacking the deck |
| Stacy Keibler | Stacy P | Stacy Prammanasudh |
| Stade de France | Stade Geoffroy-Guichard | Stade Pierre-Mauroy |
| Stade Rennais F.C. | Stade Vélodrome | Stadio delle Alpi |
| Stadio Olimpico | Stadium | Stadium Municipal |
| Stadium municipal de Toulouse | Stadium of Light | Staff of Moses |
| Staffordshire | Stag beetle | Stage Fighter |
| Stained glass | Stained glass window | Stairway to Heaven |
| Stairway to Heaven (TV series) | Stakker Humanoid | Stalin |
| Stalingrad | Stalingrad (2013 film) | Stamford Bridge (stadium) |
| Stamford, Connecticut | Stan Getz | Stan Hansen |
| Stan Lee | Stan Stasiak | Stand by Me (film) |
| STAND BY ME: โดราเอมอน เพื่อนกันตลอดไป (2014) | Standard & Poor's | Standard Cantonese |
| Standard Chartered | Standard Chinese | Standard deviation |
| Standard gauge | Standard Industrial Classification | Standard temperature and pressure |
| Standby | Standing moonsault | Standing Shiranui |
| Stanford | Stanford prison experiment | Stanford University |
| Stanislav Cherchesov | Stanley Baldwin | Stanley Kubrick |
| Stanley Tong | Stanley Tucci | Stanserhorn |
